ZACH ROSENTHAL MD, PHD
I was with the Lee Lab 2015-2020. My primary interest is in the mechanistic underpinnings of brain connectivity, in particular how brain networks remodel after injuries like stroke, and how we can enlist targeted therapies for rewiring these connections. I use transgenic mice combined with viral gene editing to model human brain networks and targeted therapies, and then study the effects of these manipulations using optical neuroimaging and electrophysiological tools. My goals are to understand the role of the brain’s GABAergic inhibitory circuitry in mediating plasticity in cortical networks, as well as other cell-type specific contributions to network dynamics in the healthy brain.