Welcome to the Lee Research Laboratory

We are engaged in translational research to investigate cellular and molecular mechanisms involved in acute and chronic brain injury, with a focus on Ischemic stroke and Alzheimer’s disease.  An additional focus of the lab is neuroplasticity and brain repair after stroke.  A major motivation of the lab is to identify strategies and targets for mitigating brain injury and enhancing brain repair after injury.  The lab utilizes cutting-edge approaches in molecular biology, mouse genetics, neuroimaging (microscopic and mesoscopic), advanced image analysis (data-driven and machine learning approaches), advanced statistical approaches, and genomics.  A unique aspect of the Lee lab is its bi-directional approach to translational research—taking advantage of both traditional forward-translational (bench-to-bedside) as well as reverse-translational (bedside-to-bench) approaches.  Thus, the lab is facile in both human clinical studies, as well as studies utilizing cellular and animal models of disease.


News

The Naked Scientist
Faster stroke recovery in mice

Wustl News Hub
Stroke recovery improved by sensory deprivation, mouse study shows

KMOV
Coronavirus Could Raise Rise of Strokes in Young Adults

St. Louis Post-Dispatch
St. Louis-area doctors look at connections between strokes and COVID-19