Welcome to the Lee Research Laboratory

We are engaged in translational research to investigate cellular and molecular mechanisms involved in acute and chronic brain injury, with a focus on Ischemic stroke and Alzheimer’s disease.  An additional focus of the lab is neuroplasticity and brain repair after stroke.  A major motivation of the lab is to identify strategies and targets for mitigating brain injury and enhancing brain repair after injury.  The lab utilizes cutting-edge approaches in molecular biology, mouse genetics, neuroimaging (microscopic and mesoscopic), advanced image analysis (data-driven and machine learning approaches), advanced statistical approaches, and genomics.  A unique aspect of the Lee lab is its bi-directional approach to translational research—taking advantage of both traditional forward-translational (bench-to-bedside) as well as reverse-translational (bedside-to-bench) approaches.  Thus, the lab is facile in both human clinical studies, as well as studies utilizing cellular and animal models of disease


Division of Physician-Scientists September 2022 Newsletter

Wustl News Hub
Lee named head of Department of Neurology

Stroke recovery improved by sensory deprivation, mouse study shows

Calming overexcited neurons may protect brain after stroke

The Best Time For Rehabilitation After A Stroke Might Actually Be 2 To 3 Months Later

How to recognize when a person is having a stroke

The Naked Scientist
Faster stroke recovery in mice

Coronavirus Could Raise Rise of Strokes in Young Adults

St. Louis Post-Dispatch
St. Louis-area doctors look at connections between strokes and COVID-19