Bedside to Bench Cerebral Blood flow & Oxygen Metabolism in Ischemic Brain Injury Pathophysiology of Cantu Syndrome Pathophysiology of Cerebral Small Vessel Disease Pathophysiology of Sickle Cell Disease Genomics Identifying Molecular Targets for Acute Ischemic Stroke Image Analysis & Genomics of Cerebral Small Vessel Disease Understanding Pathways involved in Post-stroke Edema